Osteoprotegerin

A secreted member of the TNF receptor superfamily that negatively regulates osteoclastogenesis. It is a soluble decoy receptor of RANK LIGAND that inhibits both CELL DIFFERENTIATION and function of OSTEOCLASTS by inhibiting the interaction between RANK LIGAND and RECEPTOR ACTIVATOR OF NUCLEAR FACTOR-KAPPA B.

Also Known As:

FDCR-1 Protein; Follicular Dendritic Cell-Derived Receptor-1; OCIF Protein; Tumor Necrosis Factor Receptor 11b; FDCR 1 Protein; Follicular Dendritic Cell Derived Receptor 1; Osteoclastogenesis Inhibitory Factor; Receptors, Tumor Necrosis Factor, Member 11b; Tumor Necrosis Factor Receptor Superfamily, Member 11b

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Membrane Proteins: 10078
    - Cell Surface Receptors: 2125
      - Immunologic Receptors: 9
        Cytokine Receptors: 1620
        Tumor Necrosis Factor Receptors: 3685
        Tumor Necrosis Factor Decoy Receptors: 3
        Osteoprotegerin: 2491

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Disease

Drug/Important Bio-Agent (IBA)